Ontology highlight
ABSTRACT:
SUBMITTER: Morris MK
PROVIDER: S-EPMC5080650 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Morris M K MK Clarke D C DC Osimiri L C LC Lauffenburger D A DA
CPT: pharmacometrics & systems pharmacology 20160827 10
A major challenge in developing anticancer therapies is determining the efficacies of drugs and their combinations in physiologically relevant microenvironments. We describe here our application of "constrained fuzzy logic" (CFL) ensemble modeling of the intracellular signaling network for predicting inhibitor treatments that reduce the phospho-levels of key transcription factors downstream of growth factors and inflammatory cytokines representative of hepatocellular carcinoma (HCC) microenviron ...[more]