Shorter telomere length in Europeans than in Africans due to polygenetic adaptation.
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ABSTRACT:
SUBMITTER: Hansen ME
PROVIDER: S-EPMC5081046 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Publications
Shorter telomere length in Europeans than in Africans due to polygenetic adaptation.
Hansen Matthew E B ME Hunt Steven C SC Stone Rivka C RC Horvath Kent K Herbig Utz U Ranciaro Alessia A Hirbo Jibril J Beggs William W Reiner Alexander P AP Wilson James G JG Kimura Masayuki M De Vivo Immaculata I Chen Maxine M MM Kark Jeremy D JD Levy Daniel D Nyambo Thomas T Tishkoff Sarah A SA Aviv Abraham A
Human molecular genetics 20160302 11
Leukocyte telomere length (LTL), which reflects telomere length in other somatic tissues, is a complex genetic trait. Eleven SNPs have been shown in genome-wide association studies to be associated with LTL at a genome-wide level of significance within cohorts of European ancestry. It has been observed that LTL is longer in African Americans than in Europeans. The underlying reason for this difference is unknown. Here we show that LTL is significantly longer in sub-Saharan Africans than in both ...[more]
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