Ontology highlight
ABSTRACT:
SUBMITTER: Gilly A
PROVIDER: S-EPMC5081052 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Human molecular genetics 20160504 11
Cohort-wide very low-depth whole-genome sequencing (WGS) can comprehensively capture low-frequency sequence variation for the cost of a dense genome-wide genotyping array. Here, we analyse 1x sequence data across the APOC3 gene in a founder population from the island of Crete in Greece (n = 1239) and find significant evidence for association with blood triglyceride levels with the previously reported R19X cardioprotective null mutation (β = -1.09,σ = 0.163, P = 8.2 × 10<sup>-11</sup>) and a seco ...[more]