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Structure of a novel 13 nm dodecahedral nanocage assembled from a redesigned bacterial microcompartment shell protein.

ABSTRACT: We report the crystal structure of a novel 60-subunit dodecahedral cage that results from self-assembly of a re-engineered version of a natural protein (PduA) from the Pdu microcompartment shell. Biophysical data illustrate the dependence of assembly on solution conditions, opening up new applications in microcompartment studies and nanotechnology.

SUBMITTER: Jorda J 

PROVIDER: S-EPMC5081076 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature

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Structure of a novel 13 nm dodecahedral nanocage assembled from a redesigned bacterial microcompartment shell protein.

Jorda J J   Leibly D J DJ   Thompson M C MC   Yeates T O TO  

Chemical communications (Cambridge, England) 20160318 28

We report the crystal structure of a novel 60-subunit dodecahedral cage that results from self-assembly of a re-engineered version of a natural protein (PduA) from the Pdu microcompartment shell. Biophysical data illustrate the dependence of assembly on solution conditions, opening up new applications in microcompartment studies and nanotechnology. ...[more]

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