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Fingolimod: A Disease-Modifier Drug in a Mouse Model of Amyotrophic Lateral Sclerosis.

ABSTRACT: Fingolimod phosphate (FTY720), the first approved oral therapy for multiple sclerosis, primarily acts as an immunomodulator. Its concomitant effects in the central nervous system, however, indicate a potentially broader spectrum of activity in neurodegenerative diseases. In the present study, we investigated the possible effects of fingolimod in a mouse model of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by a strong neuroinflammatory component. Fingolimod (0.1 and 1 mg/kg i.p.) was administered to mSOD1G93A mice, a well-characterized mouse model of ALS, starting from the onset of motor symptoms to the end stage of the disease. The drug was able to improve the neurological phenotype (p?

SUBMITTER: Potenza RL

PROVIDER: S-EPMC5081121 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature

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Fingolimod: A Disease-Modifier Drug in a Mouse Model of Amyotrophic Lateral Sclerosis.

Potenza Rosa Luisa RL De Simone Roberta R Armida Monica M Mazziotti Valentina V Pèzzola Antonella A Popoli Patrizia P Minghetti Luisa L

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20161001 4

Fingolimod phosphate (FTY720), the first approved oral therapy for multiple sclerosis, primarily acts as an immunomodulator. Its concomitant effects in the central nervous system, however, indicate a potentially broader spectrum of activity in neurodegenerative diseases. In the present study, we investigated the possible effects of fingolimod in a mouse model of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by a strong neuroinflammatory component. Fingolimod (0.1 ...[more]

PMID: 27456702

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Amyotrophic lateral sclerosis: SOD1 mouse model

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Project description:This SuperSeries is composed of the SubSeries listed below.

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