Ontology highlight
ABSTRACT:
SUBMITTER: Potenza RL
PROVIDER: S-EPMC5081121 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Potenza Rosa Luisa RL De Simone Roberta R Armida Monica M Mazziotti Valentina V Pèzzola Antonella A Popoli Patrizia P Minghetti Luisa L
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20161001 4
Fingolimod phosphate (FTY720), the first approved oral therapy for multiple sclerosis, primarily acts as an immunomodulator. Its concomitant effects in the central nervous system, however, indicate a potentially broader spectrum of activity in neurodegenerative diseases. In the present study, we investigated the possible effects of fingolimod in a mouse model of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by a strong neuroinflammatory component. Fingolimod (0.1 ...[more]