Ontology highlight
ABSTRACT:
SUBMITTER: Perkins GD
PROVIDER: S-EPMC5081174 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Perkins Gavin D GD Quinn Tom T Deakin Charles D CD Nolan Jerry P JP Lall Ranjit R Slowther Anne-Marie AM Cooke Matthew M Lamb Sarah E SE Petrou Stavros S Achana Felix F Finn Judith J Jacobs Ian G IG Carson Andrew A Smyth Mike M Han Kyee K Byers Sonia S Rees Nigel N Whitfield Richard R Moore Fionna F Fothergill Rachael R Stallard Nigel N Long John J Hennings Susie S Horton Jessica J Kaye Charlotte C Gates Simon S
Resuscitation 20160917
Despite its use since the 1960s, the safety or effectiveness of adrenaline as a treatment for cardiac arrest has never been comprehensively evaluated in a clinical trial. Although most studies have found that adrenaline increases the chance of return of spontaneous circulation for short periods, many studies found harmful effects on the brain and raise concern that adrenaline may reduce overall survival and/or good neurological outcome. The PARAMEDIC-2 trial seeks to determine if adrenaline is s ...[more]