Link-Polymorphism of 5-HTT Promoter Region Is Associated with Autoantibodies in Patients with Systemic Lupus Erythematosus.
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SUBMITTER: Li S
PROVIDER: S-EPMC5081431 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
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Link-Polymorphism of 5-HTT Promoter Region Is Associated with Autoantibodies in Patients with Systemic Lupus Erythematosus.
Li Shu S Liu Shuang S Chen Fan F Cheng Yuqi Y Bai Ru R Lai Aiyun A Lu Zhaoping Z Xu Jian J
Journal of immunology research 20161013
Serotonin transporter linked polymorphic region (5-HTTLPR) was reported to associate with depression in systemic lupus erythematosus (SLE) patients by our team. To explore whether 5-HTTLPR plays a role in the pathogenesis of SLE, we tested 138 SLE patients and 138 age and sex matched health controls (HCs) for 5-HTTLPR by polymerase chain reaction (PCR) and agarose gel electrophoresis. Interestingly, the results suggest that the frequencies of SS genotype and S allele in SLE patients with positiv ...[more]
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