Ontology highlight
ABSTRACT:
SUBMITTER: Pham TD
PROVIDER: S-EPMC5081517 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Pham Ted D TD Pham Phi Q PQ Li Jinfeng J Letai Anthony G AG Wallace Douglas C DC Burke Peter J PJ
Scientific reports 20161027
The intrinsic apoptotic pathway and the resultant mitochondrial outer membrane permeabilization (MOMP) via BAK and BAX oligomerization, cytochrome c (cytc) release, and caspase activation are well studied, but their effect on cytosolic pH is poorly understood. Using isolated mitochondria, we show that MOMP results in acidification of the surrounding medium. BAK conformational changes associated with MOMP activate the OMA1 protease to cleave OPA1 resulting in remodeling of the cristae and release ...[more]