Ontology highlight
ABSTRACT:
SUBMITTER: Zolotarev NA
PROVIDER: S-EPMC5081699 | biostudies-literature | 2016 Jul-Sep
REPOSITORIES: biostudies-literature
Zolotarev N A NA Maksimenko O G OG Georgiev P G PG Bonchuk A N AN
Acta naturae 20160701 3
Many arthropod zinc-finger transcription factors contain a N-terminal domain called ZAD (Zinc-finger Associated Domain), which consists of four cysteines coordinating a single zinc ion. Dimerization ability has been shown for several ZAD-domains. The functional role of this domain is poorly understood. In this paper, we demonstrate that a point mutation within the ZAD-domain of the Zw5 insulator protein disrupts its nuclear localization without affecting its dimerization ability. The importance ...[more]