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Photothermal effect of gold nanostar patterns inkjet-printed on coated paper substrates with different permeability.

ABSTRACT: Inkjet printing of spherical gold nanoparticles is widely applied in the fabrication of analytical and diagnostics tools. These methods could be extended to non-spherical gold nanoparticles that can efficiently release heat locally when irradiated in the near infrared (NIR) wavelength region, due to localized surface plasmon resonance (LSPR). However, this promising application requires the ability to maintain high efficiency and tunability of the NIR LSPR of the printed nanoparticles. In this study stable inks containing PEGylated gold nanostars (GNS) were fabricated and successfully inkjet-printed onto differently coated paper substrates with different porosity and permeability. A pronounced photothermal effect was observed under NIR excitation of LSPR of the printed GNS patterns even at low laser intensities. It was found that beside the direct role of the laser intensity, this effect depends appreciably on the printing parameters, such as drop density (?, drops/mm²) and number of printed layers, and, critically, on the permeability of the coated paper substrates. These results will promote the development of GNS-based printed platforms for local photothermal therapy.

SUBMITTER: Borzenkov M

PROVIDER: S-EPMC5082577 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Photothermal effect of gold nanostar patterns inkjet-printed on coated paper substrates with different permeability.

Borzenkov Mykola M Määttänen Anni A Ihalainen Petri P Collini Maddalena M Cabrini Elisa E Dacarro Giacomo G Pallavicini Piersandro P Chirico Giuseppe G

Beilstein journal of nanotechnology 20161019

Inkjet printing of spherical gold nanoparticles is widely applied in the fabrication of analytical and diagnostics tools. These methods could be extended to non-spherical gold nanoparticles that can efficiently release heat locally when irradiated in the near infrared (NIR) wavelength region, due to localized surface plasmon resonance (LSPR). However, this promising application requires the ability to maintain high efficiency and tunability of the NIR LSPR of the printed nanoparticles. In this s ...[more]

PMID: 27826523

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Project description:Cancer combination therapy can improve treatment efficacy and is widely utilized in the biomedical field. In this paper, we propose a facile strategy to develop a polydopamine (PDA)-coated Au nanostar (NS@PPFA) as a multifunctional nanoplatform for cancer targeting and combination therapy. The Au nanostar demonstrated high photothermal conversion efficiency because of the tip-enhanced plasmonic effect. Modification of PDA and folic acid on the NS surface improved its drug-loading efficiency and targeting capability. In vitro, compared with nontargeted cells, targeted breast cancer MCF-7 cells demonstrated efficient uptake of chemodrug-loaded NS-D@PPFA through the receptor-mediated endocytosis pathway. In combination with the photothermal effect induced by near-infrared laser irradiation, controlled payload release could be activated in response to both internal (acid) and external (photothermal) stimuli, leading to an efficient chemo-photothermal action against MCF-7 cells and drug-resistant MCF-7/ADR cells. By contrast, cellular damage was less obvious in normal HaCaT (human skin keratinocytes) and NIH-3T3 cells (murine fibroblasts). In addition, payload-free NS@PPFA exhibited a high binding affinity (K d = 2.68 × 10-10 M) toward vascular endothelial growth factor (VEGF-A165), which was at least two orders of magnitude stronger than that of highly abundant plasma proteins, such as human serum albumin. Furthermore, in vitro study showed that NS@PPFA could effectively inhibit VEGF-A165-induced proliferation, migration, and tube formation of human umbilical vein endothelial cells, resulting in additional therapeutic benefits for eradicating tumors through a simultaneous antiangiogenic action in chemo-photothermal treatment. The combined treatment also exhibited the lowest microvessel density, leading to a potent antitumor effect in vivo. Overall, our "all-in-one" nanoplatform is highly promising for tumor therapy, enabling effective treatment against multidrug-resistant cancers.

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Photothermal effect of gold nanostar patterns inkjet-printed on coated paper substrates with different permeability.

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Photothermal effect of gold nanostar patterns inkjet-printed on coated paper substrates with different permeability.

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