Ontology highlight
ABSTRACT:
SUBMITTER: Montes de Oca M
PROVIDER: S-EPMC5082731 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Montes de Oca Marcela M Kumar Rajiv R Rivera Fabian de Labastida FL Amante Fiona H FH Sheel Meru M Faleiro Rebecca J RJ Bunn Patrick T PT Best Shannon E SE Beattie Lynette L Ng Susanna S SS Edwards Chelsea L CL Boyle Glen M GM Price Ric N RN Anstey Nicholas M NM Loughland Jessica R JR Burel Julie J Doolan Denise L DL Haque Ashraful A McCarthy James S JS Engwerda Christian R CR
Cell reports 20161001 2
The development of immunoregulatory networks is important to prevent disease. However, these same networks allow pathogens to persist and reduce vaccine efficacy. Here, we identify type I interferons (IFNs) as important regulators in developing anti-parasitic immunity in healthy volunteers infected for the first time with Plasmodium falciparum. Type I IFNs suppressed innate immune cell function and parasitic-specific CD4<sup>+</sup> T cell IFNγ production, and they promoted the development of pa ...[more]