Ontology highlight
ABSTRACT:
SUBMITTER: Liu R
PROVIDER: S-EPMC5082760 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Liu Renjing R Kim Kun-Yong KY Jung Yong-Wook YW Park In-Hyun IH
Scientific reports 20161018
DNA methylation is an important epigenetic mark that regulates gene expression. Dnmt1 plays an important role in maintaining DNA methylation patterns on daughter DNA strands. Studies have shed light into the functional role of Dnmt1 regulation in the hematopoietic and epidermal systems. Here we show that Dnmt1 is required for myogenesis. Loss of Dnmt1 results in reduced expression of myogenic genes and defects in myogenic differentiation. We have utilized a conditional knockout mouse approach to ...[more]