Ontology highlight
ABSTRACT:
SUBMITTER: Xia D
PROVIDER: S-EPMC5082784 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Xia Dan D Qu Liujing L Li Ge G Hongdu Beiqi B Xu Chentong C Lin Xin X Lou Yaxin Y He Qihua Q Ma Dalong D Chen Yingyu Y
Autophagy 20160616 9
MARCH2 (membrane-associated RING-CH protein 2), an E3 ubiquitin ligase, is mainly associated with the vesicle trafficking. In the present study, for the first time, we demonstrated that MARCH2 negatively regulates autophagy. Our data indicated that overexpression of MARCH2 impaired autophagy, as evidenced by attenuated levels of LC3B-II and impaired degradation of endogenous and exogenous autophagic substrates. By contrast, loss of MARCH2 expression had the opposite effects. In vivo experiments ...[more]