Ontology highlight
ABSTRACT:
SUBMITTER: Cheli VT
PROVIDER: S-EPMC5083013 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
The Journal of neuroscience : the official journal of the Society for Neuroscience 20161001 42
To determine whether L-type voltage-operated Ca<sup>2+</sup> channels (L-VOCCs) are required for oligodendrocyte progenitor cell (OPC) development, we generated an inducible conditional knock-out mouse in which the L-VOCC isoform Cav1.2 was postnatally deleted in NG2-positive OPCs. A significant hypomyelination was found in the brains of the Cav1.2 conditional knock-out (Cav1.2<sup>KO</sup>) mice specifically when the Cav1.2 deletion was induced in OPCs during the first 2 postnatal weeks. A decr ...[more]