Ontology highlight
ABSTRACT:
SUBMITTER: Kelesidis T
PROVIDER: S-EPMC5083154 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Kelesidis Theodoros T Jackson Nicholas N McComsey Grace A GA Wang Xiaoyan X Elashoff David D Dube Michael P MP Brown Todd T TT Yang Otto O OO Stein James H JH Currier Judith S JS
AIDS (London, England) 20161101 17
<h4>Objective</h4>The pathogenesis of immune dysfunction in chronic HIV-1 infection is unclear, and a potential role for oxidized lipids has been suggested. We hypothesize that both oxidized HDL and LDL (HDLox and LDLox) contribute to HIV-1-related immune dysfunction.<h4>Study</h4>In the AIDS Clinical Trials Group A5260, 234 HIV-infected antiretroviral therapy (ART)-naive participants were randomized to receive tenofovir-emtricitabine and protease inhibitors or raltegravir and had HIV-1 RNA less ...[more]