Ontology highlight
ABSTRACT:
SUBMITTER: Karimov RR
PROVIDER: S-EPMC5084078 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
ACS central science 20161007 10
Selective functionalization of complex scaffolds is a promising approach to alter the pharmacological profiles of natural products and their derivatives. We report the site-selective azidation of benzylic and aliphatic C-H bonds in complex molecules catalyzed by the combination of Fe(OAc)<sub>2</sub> and a PyBox ligand. The same system also catalyzes the trifluoromethyl azidation of olefins to form derivatives of natural products containing both fluorine atoms and azides. In general, both reacti ...[more]