Ontology highlight
ABSTRACT:
SUBMITTER: Sturgill EG
PROVIDER: S-EPMC5084272 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
The Journal of cell biology 20160418 2
The microtubule (MT) cytoskeleton bipolarizes at the onset of mitosis to form the spindle. In animal cells, the kinesin-5 Eg5 primarily drives this reorganization by actively sliding MTs apart. Its primacy during spindle assembly renders Eg5 essential for mitotic progression, demonstrated by the lethal effects of kinesin-5/Eg5 inhibitors (K5Is) administered in cell culture. However, cultured cells can acquire resistance to K5Is, indicative of alternative spindle assembly mechanisms and/or pharma ...[more]