Application of RNAi-induced gene expression profiles for prognostic prediction in breast cancer.
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ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC5084341 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Publications
Application of RNAi-induced gene expression profiles for prognostic prediction in breast cancer.
Wang Yue Y Mark Kenneth M K KM Ung Matthew H MH Kettenbach Arminja A Miller Todd T Xu Wei W Cheng Wenqing W Xia Tian T Cheng Chao C
Genome medicine 20161027 1
Homologous recombination (HR) is the primary pathway for repairing double-strand DNA breaks implicating in the development of cancer. RNAi-based knockdowns of BRCA1 and RAD51 in this pathway have been performed to investigate the resulting transcriptomic profiles. Here we propose a computational framework to utilize these profiles to calculate a score, named RNA-Interference derived Proliferation Score (RIPS), which reflects cell proliferation ability in individual breast tumors. RIPS is predict ...[more]
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