Regulation of morphine-induced synaptic alterations: Role of oxidative stress, ER stress, and autophagy.
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ABSTRACT:
SUBMITTER: Cai Y
PROVIDER: S-EPMC5084649 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Publications
Regulation of morphine-induced synaptic alterations: Role of oxidative stress, ER stress, and autophagy.
Cai Yu Y Yang Lu L Hu Guoku G Chen Xufeng X Niu Fang F Yuan Li L Liu Han H Xiong Huangui H Arikkath Jyothi J Buch Shilpa S
The Journal of cell biology 20161017 2
Our findings suggest that morphine dysregulates synaptic balance in the hippocampus, a key center for learning and memory, via a novel signaling pathway involving reactive oxygen species (ROS), endoplasmic reticulum (ER) stress, and autophagy. We demonstrate in this study that exposure of morphine to hippocampal neurons leads to a reduction in excitatory synapse densities with a concomitant enhancement of inhibitory synapse densities via activation of the μ opioid receptor. Furthermore, these ef ...[more]
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