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WDR26 is a new partner of Axin1 in the canonical Wnt signaling pathway.

ABSTRACT: The stability of ?-catenin is very important for canonical Wnt signaling. A protein complex including Axin/APC/GSK3? phosphorylates ?-catenin to be degraded by ubiquitination with ?-TrCP. In the recent study, we isolated WDR26, a protein that binds to Axin. Here, we found that WDR26 is a negative regulator of the canonical Wnt signaling pathway, and that WDR26 affected ?-catenin levels. In addition, WDR26/Axin binding is involved in the ubiquitination of ?-catenin. These results suggest that WDR26 plays a negative role in ?-catenin degradation in the Wnt signaling pathway.

SUBMITTER: Goto T

PROVIDER: S-EPMC5084729 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature

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WDR26 is a new partner of Axin1 in the canonical Wnt signaling pathway.

Goto Toshiyasu T Matsuzawa Junhei J Iemura Shun-Ichiro S Natsume Tohru T Shibuya Hiroshi H

FEBS letters 20160503 9

The stability of β-catenin is very important for canonical Wnt signaling. A protein complex including Axin/APC/GSK3β phosphorylates β-catenin to be degraded by ubiquitination with β-TrCP. In the recent study, we isolated WDR26, a protein that binds to Axin. Here, we found that WDR26 is a negative regulator of the canonical Wnt signaling pathway, and that WDR26 affected β-catenin levels. In addition, WDR26/Axin binding is involved in the ubiquitination of β-catenin. These results suggest that WDR ...[more]

PMID: 27098453

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