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Current densities and total contact currents during forest clearing tasks under 400?kV power lines.

ABSTRACT: The aim of the study was to analyze all values of electric currents from measured periods while performing tasks in forest clearing. The objective was also to choose and analyze measurement cases, where current measurements successfully lasted the entire work period (about 30?min). Two forestry workers volunteered to perform four forest clearing tasks under 400?kV power lines. The sampling frequency of the current measurements was 1?sample/s. The maximum values of the current densities were 1.0-1.2?mA/m(2) (calculated internal EFs 5.0-12.0?mV/m), and the average values were 0.2-0.4?mA/m(2) . The highest contact current was 167.4??A. All measured values during forest clearing tasks were lower than basic restrictions (0.1?V/m and 0.8?V/m) of the International Commission on Non-Ionizing Radiation Protection. Bioelectromagnetics. 37:423-428, 2016. © 2016 The Authors. Bioelectromagnetics published by Wiley Periodicals, Inc.

SUBMITTER: Korpinen L

PROVIDER: S-EPMC5084735 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature

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Current densities and total contact currents during forest clearing tasks under 400 kV power lines.

Korpinen Leena L Kuisti Harri H Elovaara Jarmo J

Bioelectromagnetics 20160518 6

The aim of the study was to analyze all values of electric currents from measured periods while performing tasks in forest clearing. The objective was also to choose and analyze measurement cases, where current measurements successfully lasted the entire work period (about 30 min). Two forestry workers volunteered to perform four forest clearing tasks under 400 kV power lines. The sampling frequency of the current measurements was 1 sample/s. The maximum values of the current densities were 1.0- ...[more]

PMID: 27192179

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Project description:Oxidative stress contributes to the arrhythmogenic substrate created by myocardial ischemia-reperfusion partly through a shift in cell redox state, a key modulator of protein function. The activity of many oxidation-sensitive proteins is controlled by oxidoreductase systems that regulate the redox state of cysteine thiol groups, but the impact of these systems on ion channel function is not well defined. Thus, we examined the roles of the thioredoxin and glutaredoxin systems in controlling K(+) channels in the ventricle. An oxidative shift in redox state was elicited in isolated rat ventricular myocytes by brief exposure to diamide, a thiol-specific, membrane-permeable oxidant. Voltage-clamp studies showed that diamide decreased peak outward K(+) current (I(peak)) evoked by depolarizing test pulses by 41% (+60 mV; p<0.05) while steady-state outward current (I(ss)) measured at the end of the test pulse was decreased by 45% (p<0.05). These electrophysiological effects were not prevented by protein kinase C blockers, but the tyrosine kinase inhibitors genistein or lavendustin A blocked the suppression of both K(+) currents by diamide. Moreover, inhibition of I(peak) and I(ss) by diamide was reversed by dichloroacetate and an insulin-mimetic. The effect of dichloroacetate to normalize I(peak) after diamide was blocked by the thioredoxin system inhibitors auranofin or 13-cis-retinoic acid, but I(ss) was not affected by either compound. A pan-specific inhibitor of glutaredoxin and thioredoxin systems, 1,3-bis-(2-chloroethyl)-1-nitrosourea, also blocked the dichloroacetate effect on I(peak) but only partially inhibited the recovery of I(ss). These data suggest that acute regulation of cardiac K(+) channels by oxidoreductase systems is mediated by redox-sensitive tyrosine kinase/phosphatase pathways. The pathways controlling I(peak) channels are targets of the thioredoxin system whereas those regulating I(ss) channels are likely controlled by the glutaredoxin system. Thus, cardiac oxidoreductase systems may be important regulators of ion channels affected by pathogenic oxidative stress.

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Current densities and total contact currents during forest clearing tasks under 400?kV power lines.

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Current densities and total contact currents during forest clearing tasks under 400 kV power lines.

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