Ontology highlight
ABSTRACT:
SUBMITTER: Trepiccione F
PROVIDER: S-EPMC5084887 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Trepiccione Francesco F Gerber Simon D SD Grahammer Florian F López-Cayuqueo Karen I KI Baudrie Véronique V Păunescu Teodor G TG Capen Diane E DE Picard Nicolas N Alexander R Todd RT Huber Tobias B TB Chambrey Regine R Brown Dennis D Houillier Pascal P Eladari Dominique D Simons Matias M
Journal of the American Society of Nephrology : JASN 20160404 11
ATPase H<sup>+</sup>-transporting lysosomal accessory protein 2 (Atp6ap2), also known as the (pro)renin receptor, is a type 1 transmembrane protein and an accessory subunit of the vacuolar H<sup>+</sup>-ATPase (V-ATPase) that may also function within the renin-angiotensin system. However, the contribution of Atp6ap2 to renin-angiotensin-dependent functions remains unconfirmed. Using mice with an inducible conditional deletion of Atp6ap2 in mouse renal epithelial cells, we found that decreased V- ...[more]