Ontology highlight
ABSTRACT:
SUBMITTER: Perry HM
PROVIDER: S-EPMC5084889 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Journal of the American Society of Nephrology : JASN 20160309 11
Epithelial and endothelial injury and a cascade of immune and interstitial cell activation in the kidney lead to AKI. After mild to moderate AKI, the epithelium can regenerate and restore kidney function, yet little is known about the endothelium during these repair processes. Sphingosine 1-phosphate receptor 1 (S1P1), a G protein-coupled receptor, is necessary for vascular homeostasis. Here, we used an inducible genetic approach in a mouse model of AKI, ischemia-reperfusion injury (IRI), to det ...[more]