Ontology highlight
ABSTRACT:
SUBMITTER: Gao Y
PROVIDER: S-EPMC5085109 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Gao Yinjie Y Liu Yuan Y Yang Mei M Guo Xiaodong X Zhang Min M Li Hanwei H Li Jin J Zhao Jingmin J
Oncotarget 20160601 23
The aim of our work was to investigate the role of interleukin-33 (IL-33) and its receptor ST2 in the progression of diet-induced nonalcoholic steatohepatitis (NASH) in mice, and the characteristic expression in livers of patients with NASH. Mice were fed with high-fat diet (HFD) or methionine-choline 4-deficient diet (MCD) and injected intraperitoneally with IL-33. Both mRNA and protein expression levels of IL-33 and ST2 were up-regulated in the livers of mice fed with HFD or MCD. Treatment wit ...[more]