Ontology highlight
ABSTRACT:
SUBMITTER: Rabinovich D
PROVIDER: S-EPMC5086089 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Rabinovich Dana D Yaniv Shiri P SP Alyagor Idan I Schuldiner Oren O
Cell 20160101 1-2
During development, neurons switch among growth states, such as initial axon outgrowth, axon pruning, and regrowth. By studying the stereotypic remodeling of the Drosophila mushroom body (MB), we found that the heme-binding nuclear receptor E75 is dispensable for initial axon outgrowth of MB γ neurons but is required for their developmental regrowth. Genetic experiments and pharmacological manipulations on ex-vivo-cultured brains indicate that neuronally generated nitric oxide (NO) promotes prun ...[more]