A preliminary study of longitudinal neuroadaptation associated with recovery from addiction.

ABSTRACT:

Background

Few studies have explored longitudinal change in event-related brain responses during early recovery from addiction. Moreover, existing findings yield evidence of both increased and decreased signaling within reward and control centers over time. The current study explored reward- and control-related signals in a risky decision-making task and specifically investigated parametric modulations of the BOLD signal, rather than signal magnitude alone. It was hypothesized that risk-related signals during decision-making and outcome evaluation would reflect recovery and that change in specific signals would correspond with improved treatment outcomes.

Methods

Twenty-one substance dependent individuals were recruited upon enrollment in community-based substance use treatm

SUBMITTER: Forster SE 

PROVIDER: S-EPMC5086261 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature