Ontology highlight
ABSTRACT:
SUBMITTER: Li W
PROVIDER: S-EPMC5086525 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Li Wenqian W Atanassov Boyko S BS Lan Xianjiang X Mohan Ryan D RD Swanson Selene K SK Farria Aimee T AT Florens Laurence L Washburn Michael P MP Workman Jerry L JL Dent Sharon Y R SYR
Molecular and cellular biology 20161028 22
The SAGA complex contains two enzymatic modules, which house histone acetyltransferase (HAT) and deubiquitinase (DUB) activities. USP22 is the catalytic subunit of the DUB module, but two adaptor proteins, ATXN7L3 and ENY2, are necessary for DUB activity toward histone H2Bub1 and other substrates. ATXN7L3B shares 74% identity with the N-terminal region of ATXN7L3, but the functions of ATXN7L3B are not known. Here we report that ATXN7L3B interacts with ENY2 but not other SAGA components. Even tho ...[more]