Ontology highlight
ABSTRACT:
SUBMITTER: Di Pierro M
PROVIDER: S-EPMC5087044 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Di Pierro Michele M Zhang Bin B Aiden Erez Lieberman EL Wolynes Peter G PG Onuchic José N JN
Proceedings of the National Academy of Sciences of the United States of America 20160929 43
In vivo, the human genome folds into a characteristic ensemble of 3D structures. The mechanism driving the folding process remains unknown. We report a theoretical model for chromatin (Minimal Chromatin Model) that explains the folding of interphase chromosomes and generates chromosome conformations consistent with experimental data. The energy landscape of the model was derived by using the maximum entropy principle and relies on two experimentally derived inputs: a classification of loci into ...[more]