Ontology highlight
ABSTRACT:
SUBMITTER: Cowley RE
PROVIDER: S-EPMC5087064 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20161010 43
Peptidylglycine α-hydroxylating monooxygenase (PHM) and dopamine β-monooxygenase (DβM) are copper-dependent enzymes that are vital for neurotransmitter regulation and hormone biosynthesis. These enzymes feature a unique active site consisting of two spatially separated (by 11 Å in PHM) and magnetically noncoupled copper centers that enables 1e<sup>-</sup> activation of O<sub>2</sub> for hydrogen atom abstraction (HAA) of substrate C-H bonds and subsequent hydroxylation. Although the structures o ...[more]