The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice.
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ABSTRACT:
SUBMITTER: Solon-Biet SM
PROVIDER: S-EPMC5087279 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
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The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice.
Solon-Biet Samantha M SM McMahon Aisling C AC Ballard J William O JW Ruohonen Kari K Wu Lindsay E LE Cogger Victoria C VC Warren Alessandra A Huang Xin X Pichaud Nicolas N Melvin Richard G RG Gokarn Rahul R Khalil Mamdouh M Turner Nigel N Cooney Gregory J GJ Sinclair David A DA Raubenheimer David D Le Couteur David G DG Simpson Stephen J SJ
Cell metabolism 20140301 3
The fundamental questions of what represents a macronutritionally balanced diet and how this maintains health and longevity remain unanswered. Here, the Geometric Framework, a state-space nutritional modeling method, was used to measure interactive effects of dietary energy, protein, fat, and carbohydrate on food intake, cardiometabolic phenotype, and longevity in mice fed one of 25 diets ad libitum. Food intake was regulated primarily by protein and carbohydrate content. Longevity and health we ...[more]
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