Ontology highlight
ABSTRACT:
SUBMITTER: Klei LR
PROVIDER: S-EPMC5087334 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Klei Linda R LR Hu Dong D Panek Robert R Alfano Danielle N DN Bridwell Rachel E RE Bailey Kelly M KM Oravecz-Wilson Katherine I KI Concel Vincent J VJ Hess Emily M EM Van Beek Matthew M Delekta Phillip C PC Gu Shufang S Watkins Simon C SC Ting Adrian T AT Gough Peter J PJ Foley Kevin P KP Bertin John J McAllister-Lucas Linda M LM Lucas Peter C PC
Cell reports 20160901 1
Microvascular endothelial cells maintain a tight barrier to prevent passage of plasma and circulating immune cells into the extravascular tissue compartment, yet endothelial cells respond rapidly to vasoactive substances, including thrombin, allowing transient paracellular permeability. This response is a cornerstone of acute inflammation, but the mechanisms responsible are still incompletely understood. Here, we demonstrate that thrombin triggers MALT1 to proteolytically cleave cylindromatosis ...[more]