Ontology highlight
ABSTRACT:
SUBMITTER: Hubert V
PROVIDER: S-EPMC5087675 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Hubert Virginie V Peschel Andrea A Langer Brigitte B Gröger Marion M Rees Andrew A Kain Renate R
Biology open 20161015 10
Autophagy is an evolutionarily conserved process used for removing surplus and damaged proteins and organelles from the cytoplasm. The unwanted material is incorporated into autophagosomes that eventually fuse with lysosomes, leading to the degradation of their cargo. The fusion event is mediated by the interaction between the Qa-SNARE syntaxin-17 (STX17) on autophagosomes and the R-SNARE VAMP8 on lysosomes. Cells deficient in lysosome membrane-associated protein-2 (LAMP-2) have increased number ...[more]