Ontology highlight
ABSTRACT:
SUBMITTER: Hoover AR
PROVIDER: S-EPMC5087740 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Hoover Ashley R AR Dozmorov Igor I MacLeod Jessica J Du Qiumei Q de la Morena M Teresa MT Forbess Joseph J Guleserian Kristine K Cleaver Ondine B OB van Oers Nicolai S C NS
The Journal of biological chemistry 20160919 44
The thymus, an organ responsible for T cell development, is one of the more stress-sensitive tissues in the body. Stress, in the form of infections, radiation exposure, and steroids, impairs thymic epithelial cell (TEC) functions and induces the programmed cell death of immature thymocytes. MicroRNAs are small noncoding RNAs involved in tissue repair and homeostasis, with several supporting T cell development. We report that miR-205, an epithelial-specific miR, maintains thymopoiesis following i ...[more]