Ontology highlight
ABSTRACT:
SUBMITTER: Izumikawa T
PROVIDER: S-EPMC5087745 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Izumikawa Tomomi T Dejima Katsufumi K Watamoto Yukiko Y Nomura Kazuko H KH Kanaki Nanako N Rikitake Marika M Tou Mai M Murata Daisuke D Yanagita Eri E Kano Ai A Mitani Shohei S Nomura Kazuya K Kitagawa Hiroshi H
The Journal of biological chemistry 20160919 44
Chondroitin sulfate (CS)/chondroitin (Chn) chains are indispensable for embryonic cell division and cytokinesis in the early developmental stages in Caenorhabditis elegans and mice, whereas heparan sulfate (HS) is essential for axon guidance during nervous system development. These data indicate that the fundamental functions of CS and HS are conserved from worms to mammals and that the function of CS/Chn differs from that of HS. Although previous studies have shown that C. elegans produces HS a ...[more]