Meta-Analysis of Effect Sizes Reported at Multiple Time Points Using General Linear Mixed Model.

ABSTRACT: Meta-analysis of longitudinal studies combines effect sizes measured at pre-determined time points. The most common approach involves performing separate univariate meta-analyses at individual time points. This simplistic approach ignores dependence between longitudinal effect sizes, which might result in less precise parameter estimates. In this paper, we show how to conduct a meta-analysis of longitudinal effect sizes where we contrast different covariance structures for dependence between effect sizes, both within and between studies. We propose new combinations of covariance structures for the dependence between effect size and utilize a practical example involving meta-analysis of 17 trials comparing postoperative treatments for a type of cancer, where survival is measured at 6, 12, 1

SUBMITTER: Musekiwa A 

PROVIDER: S-EPMC5087886 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature