Ontology highlight
ABSTRACT:
SUBMITTER: Li D
PROVIDER: S-EPMC5088285 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Li Doudou D Qu Chao C Ning Zhouyu Z Wang Haiyong H Zang Kun K Zhuang Liping L Chen Lianyu L Wang Peng P Meng Zhiqiang Z
American journal of cancer research 20161001 10
The tumor microenvironment is of crucial importance affecting treatment and prognosis. High degree of carcinoma-associated fibroblast (CAF) infiltration occurs in pancreatic cancer, though its effect on radiotherapy remains unclear. In this study, we demonstrated that radiation enhanced the migration- and invasion-promoting capacity of CAFs both in vitro and in vivo in a lung metastasis model. Radiation exposure increased the expression of CXCL12 by CAFs. CAF-derived CXCL12 promoted tumor cell E ...[more]