Ontology highlight
ABSTRACT:
SUBMITTER: Tan B
PROVIDER: S-EPMC5088305 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Tan Botao B Luo Zeruxin Z Yue Yan Y Liu Yuan Y Pan Li L Yu Lehua L Yin Ying Y
Stem cells international 20161018
Insufficient proliferation, differentiation, and migration are the main pitfalls of neural stem cells (NSCs) in reparative therapeutics for the central nervous system (CNS) diseases. The potent lipid mediator sphingosine-1-phosphate (S1P) regulates cells' biological behavior broadly in the CNS. However, the effects of activating S1P on NSCs are not quite clear. In the current study, FTY720 (Fingolimod), an analog of S1P, was employed to induce the proliferation, differentiation, and migration of ...[more]