Ontology highlight
ABSTRACT:
SUBMITTER: Lemkul JA
PROVIDER: S-EPMC5088455 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Lemkul Justin A JA Lakkaraju Sirish Kaushik SK MacKerell Alexander D AD
ACS omega 20161026 4
Binding of metal ions is an important factor governing the folding and dynamics of RNA. Shielding of charges in the polyanionic backbone allows RNA to adopt a diverse range of folded structures that give rise to their many functions within the cell. Some RNA sequences fold only in the presence of Mg<sup>2+</sup>, which may be bound via direct interactions or occupy the more diffuse "ion atmosphere" around the RNA. To understand the driving forces for RNA folding, it is important to be able to fu ...[more]