Ontology highlight
ABSTRACT:
SUBMITTER: Sterkel AK
PROVIDER: S-EPMC5088612 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Sterkel Alana K AK Lorenzini Jenna L JL Fites J Scott JS Subramanian Vignesh Kavitha K Sullivan Thomas D TD Wuthrich Marcel M Brandhorst Tristan T Hernandez-Santos Nydiaris N Deepe George S GS Klein Bruce S BS
Cell host & microbe 20160225 3
Systemic fungal infections trigger marked immune-regulatory disturbances, but the mechanisms are poorly understood. We report that the pathogenic yeast of Blastomyces dermatitidis elaborates dipeptidyl-peptidase IVA (DppIVA), a close mimic of the mammalian ectopeptidase CD26, which modulates critical aspects of hematopoiesis. We show that, like the mammalian enzyme, fungal DppIVA cleaved C-C chemokines and GM-CSF. Yeast producing DppIVA crippled the recruitment and differentiation of monocytes a ...[more]