Night Activity Reduction is a Signature Physiological Biomarker for Duchenne Muscular Dystrophy Dogs.

ABSTRACT:

Background

Duchenne muscular dystrophy (DMD) is an X-linked lethal muscle disease. Dystrophic dogs are excellent models to test novel therapies for DMD. However, the use of the dog model has been hindered by the lack of an effective method to evaluate whole-body mobility. We recently showed that night activity is a good indicator of dog mobility. However, our published method relies on frame-by-frame manual processing of a 12-hour video for each dog. This labor-intensive and time-consuming approach makes it unrealistic to use this assay as a routine outcome measurement.

Objective

To solve this problem, we developed an automatic video-capturing/imaging processing system. The new system reduces the data analysis time over 1,000 fold and also provides a more detailed activity p

SUBMITTER: Hakim CH 

PROVIDER: S-EPMC5089072 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature