Ontology highlight
ABSTRACT:
SUBMITTER: Costanzo G
PROVIDER: S-EPMC5089550 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Costanzo Giovanna G Pino Samanta S Timperio Anna Maria AM Šponer Judit E JE Šponer Jiří J Nováková Olga O Šedo Ondrej O Zdráhal Zbyněk Z Di Mauro Ernesto E
PloS one 20161101 11
Recent studies illustrate that short oligonucleotide sequences can be easily produced from nucleotide precursors in a template-free non-enzymatic way under dehydrating conditions, i.e. using essentially dry materials. Here we report that 3',5' cyclic AMP may also serve as a substrate of the reaction, which proceeds under moderate conditions yet with a lower efficiency than the previously reported oligomerization of 3',5' cyclic GMP. Optimally the oligomerization requires (i) a temperature of 80° ...[more]