A Risk Score for Predicting Multiple Sclerosis.

ABSTRACT:

Objective

Multiple sclerosis (MS) develops as a result of environmental influences on the genetically susceptible. Siblings of people with MS have an increased risk of both MS and demonstrating asymptomatic changes in keeping with MS. We set out to develop an MS risk score integrating both genetic and environmental risk factors. We used this score to identify siblings at extremes of MS risk and attempted to validate the score using brain MRI.

Methods

78 probands with MS, 121 of their unaffected siblings and 103 healthy controls were studied. Personal history was taken, and serological and genetic analysis using the illumina immunochip was performed. Odds ratios for MS associated with each risk factor were derived from existing literature, and the log values of the odds ratio

SUBMITTER: Dobson R 

PROVIDER: S-EPMC5089761 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature