Ontology highlight
ABSTRACT:
SUBMITTER: Fu TM
PROVIDER: S-EPMC5089849 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Fu Tian-Min TM Li Yang Y Lu Alvin A Li Zongli Z Vajjhala Parimala R PR Cruz Anthony C AC Srivastava Devendra B DB DiMaio Frank F Penczek Pawel A PA Siegel Richard M RM Stacey Katryn J KJ Egelman Edward H EH Wu Hao H
Molecular cell 20161013 2
Caspase-8 activation can be triggered by death receptor-mediated formation of the death-inducing signaling complex (DISC) and by the inflammasome adaptor ASC. Caspase-8 assembles with FADD at the DISC and with ASC at the inflammasome through its tandem death effector domain (tDED), which is regulated by the tDED-containing cellular inhibitor cFLIP and the viral inhibitor MC159. Here we present the caspase-8 tDED filament structure determined by cryoelectron microscopy. Extensive assembly interfa ...[more]