Ontology highlight
ABSTRACT:
SUBMITTER: Kuang MC
PROVIDER: S-EPMC5089864 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Kuang Meihua Christina MC Hutchins Paul D PD Russell Jason D JD Coon Joshua J JJ Hittinger Chris Todd CT
eLife 20160930
The evolutionary mechanisms leading to duplicate gene retention are well understood, but the long-term impacts of paralog differentiation on the regulation of metabolism remain underappreciated. Here we experimentally dissect the functions of two pairs of ancient paralogs of the <i>GAL</i>actose sugar utilization network in two yeast species. We show that the <i>Saccharomyces uvarum</i> network is more active, even as over-induction is prevented by a second co-repressor that the model yeast <i>S ...[more]