Ontology highlight
ABSTRACT:
SUBMITTER: Isaacman S
PROVIDER: S-EPMC5090713 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Isaacman Steven S Buckley Michael M Wang Xiaojian X Wang Edwin Y EY Liebes Leonard L Canary James W JW
Bioorganic & medicinal chemistry letters 20140131 5
Nanometer-scale architectures assembled on cell surface receptors from smaller macromolecular constituents generated a large amplification of fluorescence. A targeted dendrimer was synthesized from a cystamine-core G4 PAMAM dendrimer, and contained an anti-BrE3 monoclonal antibody as the targeting group, several fluorophores and an average of 12 aldehyde moieties as complementary bio-orthogonal reactive sites for the covalent assembly. A cargo dendrimer, derived from a PAMAM G4 dendrimer, contai ...[more]