Ontology highlight
ABSTRACT:
SUBMITTER: Ilic S
PROVIDER: S-EPMC5090872 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Ilic Stefan S Akabayov Sabine R SR Arthanari Haribabu H Wagner Gerhard G Richardson Charles C CC Akabayov Barak B
Scientific reports 20161102
The structural differences between bacterial and human primases render the former an excellent target for drug design. Here we describe a technique for selecting small molecule inhibitors of the activity of T7 DNA primase, an ideal model for bacterial primases due to their common structural and functional features. Using NMR screening, fragment molecules that bind T7 primase were identified and then exploited in virtual filtration to select larger molecules from the ZINC database. The molecules ...[more]