The transcriptional modulator HMGA2 promotes stemness and tumorigenicity in glioblastoma.
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ABSTRACT:
SUBMITTER: Kaur H
PROVIDER: S-EPMC5091648 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Publications
The transcriptional modulator HMGA2 promotes stemness and tumorigenicity in glioblastoma.
Kaur Harpreet H Ali Sabeen Zulfiqar SZ Huey Lauren L Hütt-Cabezas Marianne M Taylor Isabella I Mao Xing-Gang XG Weingart Melanie M Chu Qian Q Rodriguez Fausto J FJ Eberhart Charles G CG Raabe Eric H EH
Cancer letters 20160418 1
Glioblastoma (GBM) contains a population of stem-like cells that promote tumor invasion and resistance to therapy. Identifying and targeting stem cell factors in GBM may lead to the development of more effective therapies. High Mobility Group AT-hook 2 (HMGA2) is a transcriptional modulator that mediates motility and self-renewal in normal and cancer stem cells. We identified increased expression of HMGA2 in the majority of primary human GBM tumors and cell lines compared to normal brain. Additi ...[more]
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