Dataset Information

Differential association of default mode network connectivity and rumination in healthy individuals and remitted MDD patients.

ABSTRACT: Rumination is associated with increased default-mode network (DMN) activity and functional connectivity (FC) in depressed and healthy individuals. In this study, we sought to examine the relationship between self-reported rumination and resting-state FC in the DMN and cognitive control networks in 25 remitted depressed patients and 25 matched healthy controls using independent component and seed-based analyses. We also explored potential group differences in the global pattern of resting-state FC. Healthy subjects with increased levels of rumination exhibited increased anterior DMN connectivity with the posterior DMN and the dorsal attention network and low connectivity within the anterior DMN. On the other hand, remitted depressed ruminators patients were associated with the opposite FC pattern in these regions. Based on global FC patterns, a support vector machine algorithm correctly classified 92% of the subjects into their respective group by a leave-one-out cross-validation. Whole-brain FC analysis also revealed a group by rumination interaction effect within the DMN. The present findings highlight the different functional roles of the anterior and the posterior DMN, and provide novel insights into the underlying neural mechanisms leading to depression relapse.

SUBMITTER: Lois G

PROVIDER: S-EPMC5091677 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature

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Differential association of default mode network connectivity and rumination in healthy individuals and remitted MDD patients.

Lois Giannis G Wessa Michèle M

Social cognitive and affective neuroscience 20160712 11

Rumination is associated with increased default-mode network (DMN) activity and functional connectivity (FC) in depressed and healthy individuals. In this study, we sought to examine the relationship between self-reported rumination and resting-state FC in the DMN and cognitive control networks in 25 remitted depressed patients and 25 matched healthy controls using independent component and seed-based analyses. We also explored potential group differences in the global pattern of resting-state F ...[more]

PMID: 27405616

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Project description:Resting-state functional connectivity changes in the default mode network (DMN) of patients with major depressive disorder (MDD) have been linked to rumination. The DMN is divided into three subsystems: a midline Core, a dorsal medial prefrontal cortex (DMPFC) subsystem, and a medial temporal lobe (MTL) subsystem. We examined resting-state functional connectivity within and between DMN subsystems in MDD and its association with rumination. First, we conducted a meta-analysis on a large multi-site dataset of 618 MDD and 683 controls to quantify the differences in DMN subsystem functional connectivity between MDD and controls. Second, we tested the association of DMN subsystem functional connectivity and rumination in a sample of 115 unmedicated participants with symptoms of anxiety/depression and 48 controls. In our meta-analysis, only functional connectivity in the DMN Core was significantly reduced in MDD compared to controls (g = -0.246, CI = [-0.417; -0.074], pFDR = 0.048). Functional connectivity in the DMPFC subsystem and between the Core and DMPFC subsystems was slightly reduced but not significantly (g = -0.162, CI = [-0.310; -0.013], pFDR = 0.096; g = -0.249, CI = [-0.464; -0.034], pFDR = 0.084). Results were heterogeneous across sites for connectivity in the Core and between Core and DMPFC (I2 = 0.348 and I2 = 0.576 respectively). Prediction intervals consistently encompassed 0. In the independent sample we collected, functional connectivity within the DMN Core, DMPFC and between Core and DMPFC was not reduced in MDD compared to controls (all pFDR > 0.05). Trait rumination did not predict connectivity within and between DMN subsystems (all pFDR > 0.05). We conclude that MDD as a diagnostic category shows slightly reduced functional connectivity within the DMN Core, independent of illness duration, treatment, symptoms and trait rumination. However, this effect is small, highly variable and heterogeneous across samples, so that we could only detect it at the meta-analytic level, with a sample size of several hundreds. Our results indicate that reduced Core DMN connectivity has significant limitations as a potential clinical or prognostic marker for the diagnosis of MDD and might be more relevant to consider as a characteristic distinguishing a subgroup of individuals within this diagnostic category.

Project description:IntroductionAspects of the built environment relate to health factors and equity in living conditions, and may contribute to racial, ethnic, or economic health disparities. For example, urbanicity is linked with negative factors including exposure to gray space (e.g., impervious surfaces such as concrete, streets, or rooftops). While there is existing research on access to green space and urbanicity on some mental health and cognitive outcomes, there is limited research on the presence of gray space linked with cognitive functioning in youth. The goal of this study was to investigate the link between gray space and amygdala-default mode network (DMN) connectivity.MethodsThis study used data from the ABCD Study. Participants (n = 10,144; age M = 119.11 months, female = 47.62%) underwent resting-state fMRI acquisition at baseline. Impervious surfaces (gray space) were measured via the Child Opportunity Index (COI). To examine the relationship between presence of gray space and -amygdala-DMN (left/right) connectivity, we employed linear mixed effects models. Correlations were run between amygdala-DMN connectivity and internalizing and externalizing symptoms. Finally, post hoc sensitivity analyses were run to assess the impact of race.ResultsMore gray space, adjusting for age, sex, and neighborhood-level variables, was significantly associated with increased left amygdala-DMN connectivity (p = 0.0001). This association remained significant after sensitivity analyses for race were completed (p = 0.01). No significant correlations were observed between amygdala-DMN and internalizing or externalizing symptoms.DiscussionFindings suggest gray space was linked with increased left amygdala-DMN connectivity, circuits that have been implicated in affective processing, emotion regulation, and psychopathology. Thus gray space may be related to alterations in connectivity that may enhance risk for emotion dysregulation. Future investigation of these relationships is needed, as neuroimaging findings may represent early dysregulation not yet observed in the behavioral analyses at this age (i.e., the present study did not find significant relationships with parent-reported behavioral outcomes). These findings can help to inform future public policy on improving lived and built environments.

Dataset Information

Differential association of default mode network connectivity and rumination in healthy individuals and remitted MDD patients.

Publications

Differential association of default mode network connectivity and rumination in healthy individuals and remitted MDD patients.

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