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Network integrity of the parental brain in infancy supports the development of children's social competencies.

ABSTRACT: The cross-generational transmission of mammalian sociality, initiated by the parent's postpartum brain plasticity and species-typical behavior that buttress offspring's socialization, has not been studied in humans. In this longitudinal study, we measured brain response of 45 primary-caregiving parents to their infant's stimuli, observed parent-infant interactions, and assayed parental oxytocin (OT). Intra- and inter-network connectivity were computed in three main networks of the human parental brain: core limbic, embodied simulation and mentalizing. During preschool, two key child social competencies were observed: emotion regulation and socialization. Parent's network integrity in infancy predicted preschoolers' social outcomes, with subcortical and cortical network integrity foreshadowing simple evolutionary-based regulatory tactics vs complex self-regulatory strategies and advanced socialization. Parent-infant synchrony mediated the links between connectivity of the parent's embodied simulation network and preschoolers' ability to use cognitive/executive emotion regulation strategies, highlighting the inherently dyadic nature of this network and its long-term effects on tuning young to social life. Parent's inter-network core limbic-embodied simulation connectivity predicted children's OT as moderated by parental OT. Findings challenge solipsistic neuroscience perspectives by demonstrating how the parent-offspring interface enables the brain of one human to profoundly impact long-term adaptation of another.

SUBMITTER: Abraham E

PROVIDER: S-EPMC5091682 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature

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Network integrity of the parental brain in infancy supports the development of children's social competencies.

Abraham Eyal E Hendler Talma T Zagoory-Sharon Orna O Feldman Ruth R

Social cognitive and affective neuroscience 20160630 11

The cross-generational transmission of mammalian sociality, initiated by the parent's postpartum brain plasticity and species-typical behavior that buttress offspring's socialization, has not been studied in humans. In this longitudinal study, we measured brain response of 45 primary-caregiving parents to their infant's stimuli, observed parent-infant interactions, and assayed parental oxytocin (OT). Intra- and inter-network connectivity were computed in three main networks of the human parental ...[more]

PMID: 27369068

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Project description:The home learning environment plays an important role for children's early competencies development. In particular, the early home literacy environment (HLE) that consists of all literacy resources and interactions in a family that support children's linguistic and literacy learning is closely associated with children's language comprehension and production. A key aspect of the HLE is shared reading that should start early in children's life and should be part of a regular routine in the family. However, parental attitudes toward (shared) reading have hardly been analyzed. In this longitudinal study, we analyzed the associations between parental attitudes toward shared reading and children's linguistic competencies and whether these associations may be mediated by the HLE. Further, we were interested in changes of parental attitudes over time and their association with child and family background characteristics. The sample consisted of N = 133 children with an average age of about 3 years at t1. Children were tested two more times with a 6-month period in-between each assessment. Parental attitudes toward shared reading, socioeconomic status (SES), and the HLE were assessed via parental survey. Children's sentence comprehension, productive language, and grammar were measured with a standardized test battery. Children whose parents had a more positive attitude toward shared reading not only lived in a greater quality HLE but also performed better in the linguistic tests. In a structural equation model, an indirect effect was found showing that the HLE mediated the effect of parental attitudes on children's linguistic competencies. Further, parental attitudes toward shared reading did not change significantly across t1 to t3, and a lower score in the SES scale was associated with a less positive attitude toward shared reading. Consequently, parental attitudes toward shared reading seem to be an important basis for individual differences in the quality of the HLE and also for children's linguistic competencies. As these attitudes vary in the context of different family SES backgrounds, they may be a good target for interventions to support the quality of the HLE and young children's linguistic learning.

Project description:Oxytocin (OT) has an important role in bond formation and social reciprocity, and animal studies indicate that OT functioning is transferred from parent to child through patterns of parental care. Perspectives on attachment suggest that the individual's various attachment bonds are underpinned by the oxytocinergic system. However, prospective human studies that demonstrate the cross-generation transfer of OT as mediated by early caregiving and its impact on children's multiple attachments are lacking. To address these concerns, the current study included 160 mothers and fathers and their firstborn child who participated in a 3-year longitudinal study. At the first and sixth postpartum months, parents' plasma OT was assayed, parent-infant interactions were videotaped and micro-coded, and allelic variations on the OXTR(rs2254298, rs1042778) and CD38rs3796863 genes were measured. At 3 years, parents' and child's salivary OT was assessed and children's social reciprocity observed during interactions with mother, father, and their first best friend. Parents' OT levels were individually stable across the 3-year period, correlated with low-risk OXTR and CD38 alleles, and predicted child OT. Child's social reciprocity with friend was associated with child OT levels, mother's OT-related genes and hormones, and mother-child reciprocity, but not with father's genes, hormones, or behavior. A cross-generation gene-by-environment effect emerged, with low child OT levels predicted by the interaction of maternal high-risk CD38 allele and diminished maternal care in infancy. These results demonstrate individual stability in peripheral OT across several years and describe a cross-generation transfer of OT through caregiving in humans within a prospective longitudinal design. Consistent with other mammals, biobehavioral experiences within the parent-infant bond shape children's affiliative biology and social behavior across multiple attachments. Our findings bear important implications for conditions involving disruptions to maternal-infant bonding and underscore the potential for peer-based interventions.

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Network integrity of the parental brain in infancy supports the development of children's social competencies.

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Network integrity of the parental brain in infancy supports the development of children's social competencies.

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