A Molecular Genetic Basis Explaining Altered Bacterial Behavior in Space.

ABSTRACT: Bacteria behave differently in space, as indicated by reports of reduced lag phase, higher final cell counts, enhanced biofilm formation, increased virulence, and reduced susceptibility to antibiotics. These phenomena are theorized, at least in part, to result from reduced mass transport in the local extracellular environment, where movement of molecules consumed and excreted by the cell is limited to diffusion in the absence of gravity-dependent convection. However, to date neither empirical nor computational approaches have been able to provide sufficient evidence to confirm this explanation. Molecular genetic analysis findings, conducted as part of a recent spaceflight investigation, support the proposed model. This investigation indicated an overexpression of genes associated with star

SUBMITTER: Zea L 

PROVIDER: S-EPMC5091764 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature